Key Takeaways:
- Nutrient Gaps: Ozempic users may experience reduced nutrient intake due to appetite suppression and slower digestion. This gap leads Ozempic users to question which vitamins and minerals will work best for them.
- Targeted Support: Vitamins like B-complex, magnesium, and antioxidants help support energy, nerve health, and gut balance.
- Supplement Timing: Taking supplements with meals and separate from injections may help reduce side effects and improve absorption.
Ozempic has become a widely used option for those managing blood sugar and body weight, but it also comes with changes that affect how people eat and feel. Many users report a noticeable drop in appetite, a shift in digestion, and, in some cases, symptoms like fatigue or nausea. These changes can quietly impact your daily nutrient intake and the way your body processes essential vitamins and minerals. That’s why users often at a crossroads in deciding what vitamins to take with Ozempic.
The connection between GLP-1 medications like Ozempic and nutritional support is becoming clearer. When food intake goes down or digestion slows, vitamin levels can gradually decline. Supplements are not meant to replace food, but they can help fill in nutritional gaps and support your body’s ability to adjust and function at its best. With the right approach, you can reduce discomfort and maintain better balance while continuing your medication.
We develop solutions that target these specific needs. Each of our supplements is pharmacist- and physician-formulated, made in the U.S., and manufactured in a cGMP, FDA-registered facility. We use clean, gluten-free, and research-backed ingredients to create effective formulations for everyday health concerns like nerve repair, liver support, and GLP-1 therapy side effects. Our GLP-1 support product was the first of its kind, crafted to meet the needs of those using medications like Ozempic, Wegovy, and Mounjaro.
Why Supplementing Matters When Taking Ozempic
Ozempic, a GLP-1 receptor agonist originally developed for type 2 diabetes, has become widely known for its role in weight management. But alongside its benefits, many users experience changes in appetite, digestion, and energy. These shifts can quietly impact how the body absorbs or uses certain nutrients, especially when appetite reduction leads to lower food intake overall.
Supplementation isn’t just about filling in the blanks of a restricted diet. It’s about supporting the body through change. With Ozempic’s mechanism slowing gastric emptying and reducing hunger cues, it's common for users to unintentionally reduce their intake of essential vitamins and minerals. Over time, this can influence energy levels, mood, muscle function, and even how well the gut and liver process nutrients.
That’s why more people are paying attention to how they can stay nutritionally supported while using GLP-1 medications. It’s also worth noting that certain food and beverage habits, like relying heavily on caffeine, can compound these issues. Research exploring Ozempic and coffee highlights how stimulants may interact with the digestive changes GLP-1 medications bring. This makes it even more important to support the body’s systems proactively, starting with the right nutrients at the right time.
How Ozempic May Affect Nutrient Levels
Ozempic’s influence on the digestive system is one of the reasons users often feel noticeable shifts in appetite, digestion, and energy, and this typically explains why users experiment with which vitamins to take with Ozempic. The same mechanism that slows gastric emptying to promote satiety can also alter how the body absorbs and utilizes certain nutrients. While this may not raise concern in the short term, it becomes more relevant the longer someone remains on GLP-1 therapy.
Appetite Changes and Nutrient Gaps
Reduced hunger is a key benefit of Ozempic, but it often leads to decreased calorie intake. When food quantity drops, so does the diversity and consistency of nutrients consumed. This can lead to gaps in B vitamins, magnesium, and other micronutrients that support everything from metabolism to nerve health (Medical News Today).
Slowed Digestion and Absorption Issues
With delayed gastric emptying, food sits longer in the stomach, which can impact how efficiently nutrients are absorbed. This can contribute to symptoms like reflux, bloating, and nausea, especially in the first few weeks of treatment. Nutritional strategies, such as those outlined in the Ozempic nausea relief tips and supplements to feel better guide, may help ease digestive discomfort while supporting nutrient uptake.
Long-Term Considerations for Micronutrient Health
As time on Ozempic continues, subtle signs like low energy or muscle weakness may appear. These issues are not always due to the medication itself, but to gradually declining nutrient levels. Proactive support through supplementation can help maintain balance and reduce the likelihood of depletion over time (Good RX, 2025).
Key Vitamins to Support Your Ozempic Journey
Supporting your body with targeted vitamins while on Ozempic can help reduce side effects, maintain energy, and promote balance as your dietary patterns shift. Not every supplement is necessary for everyone, but certain nutrients have shown consistent value in this context.
B Vitamins for Energy and Metabolism
Research suggests that people using GLP-1 medications often consume fewer total calories and fewer carbohydrates overall, which can naturally reduce dietary sources of thiamine (B1), B6, and B12. These vitamins play essential roles in converting food into energy, maintaining healthy nerve signaling, and supporting cognitive function. When appetite decreases or meals become smaller and less frequent, it becomes harder to maintain adequate levels—making B-complex support particularly beneficial for those experiencing fatigue, weakness, or nerve-related discomfort.
NeuraZenx® offers a pharmacist-formulated blend with bioavailable B-complex vitamins and 1200 mg of R-alpha lipoic acid, developed to support nerve health and energy metabolism.
Electrolytes and Magnesium for Muscle Function
Research suggests that reduced food intake during GLP-1 therapy may also lead to lower consumption of magnesium, sodium, and potassium—minerals that regulate muscle contraction, heart rhythm, and overall hydration. Even mild declines in these electrolytes can contribute to symptoms like muscle cramps, dizziness, or restlessness. Supporting the body with magnesium or a balanced electrolyte supplement can help maintain muscle and nerve stability as the digestive system adapts to slower gastric emptying and fewer daily calories.
Antioxidants and Gut-Supportive Nutrients
As your food intake decreases or becomes more selective, antioxidant intake may drop as well. Nutrients like zinc, selenium, and vitamin C support immune health, cellular repair, and liver function—systems that may experience additional stress when digestion slows or meal patterns change. Fermented foods, fiber-rich vegetables, and gut-friendly nutrients are also helpful. For those unsure where to start, our guide on Ozempic Foods to Avoid: What to Eat When Using Ozempic highlights smart dietary choices that can complement supplementation.
Reinforcing the diet with antioxidant-rich supplements or gut-supportive nutrients can help maintain resilience and digestive comfort throughout GLP-1 therapy.
Vitamin D for Immune and Metabolic Balance
Research suggests that individuals with reduced calorie intake during GLP-1 therapy may not meet daily vitamin D needs through diet alone. Vitamin D supports immune health, mood regulation, and metabolic function—areas that may feel more sensitive when appetite shifts or protein and dairy intake decreases. Supplementing vitamin D can help maintain bone strength and overall vitality, especially for those spending less time outdoors or eating fewer fortified foods.
Vitamin K2 for Bone and Cardiovascular Support
Because vitamin D and K2 work synergistically, research suggests that GLP-1 users may benefit from both. Vitamin K2 helps direct calcium into the bones rather than soft tissues, supporting long-term skeletal health. When meal sizes shrink, sources of K2—like fermented foods and certain animal proteins—may become less frequent, making targeted supplementation a valuable addition for comprehensive nutrient support.
Daily GLP-1 Support with PeptideVite™
Many Ozempic users experience common side effects such as nausea, bloating, and fatigue, particularly during the adjustment phase. These symptoms are often connected to changes in digestion, food intake, and nutrient absorption, making it important to support the body with a targeted supplement that aligns with GLP-1 therapy. Without that support, it's easy to feel depleted or off balance, especially as meals become smaller and digestion slows (Medical News Today).
PeptideVite™ was formulated by pharmacists and physicians with these challenges in mind. It contains a proprietary blend of 17 vitamins, minerals, and herbs, including ingredients known to support digestion, metabolism, and energy levels. Using liposomal delivery for improved bioavailability, this supplement is designed to help reduce the physical strain many users feel when adapting to Ozempic. From easing GI discomfort to addressing micronutrient gaps, it offers daily coverage that complements the nutritional shifts caused by GLP-1 use.
Produced in an FDA-registered, cGMP facility, PeptideVite™ reflects Zen Nutrients’ clean-label philosophy, free from gluten and unnecessary additives. For those navigating fatigue or digestive challenges, PeptideVite™ offers comprehensive support with clinically backed ingredients and a thoughtful formulation tailored to GLP-1 users.
Timing, Food, and Supplement Tips for Ozempic Users
Taking supplements alongside Ozempic isn’t just about what you take, but how and when you take them. Timing, food choices, and medication interactions can all influence how well nutrients are absorbed and how your body responds overall. Creating a simple, consistent supplement routine can support the effectiveness of both your medication and your nutrition strategy.
Best Time to Take Vitamins with Ozempic
While Ozempic is usually administered once weekly, many vitamins are taken daily. In general, it’s helpful to separate your vitamin intake from your injection time to minimize overlapping gastrointestinal effects. Taking supplements with a small, nutrient-rich meal can also reduce the risk of nausea and improve absorption, especially with fat-soluble vitamins like A, D, E, and K. It's also helpful to avoid taking everything at once, as spreading supplements throughout the day may ease stomach sensitivity and improve how your body utilizes them.
Foods and Beverages to Be Mindful Of
Some foods can make side effects worse or interfere with nutrient absorption. Greasy meals, alcohol, and processed sugars tend to increase bloating and nausea. In contrast, meals rich in lean protein, fiber, and healthy fats are easier to tolerate and can work in synergy with your supplements. Users should also be mindful of liver health, especially when dietary patterns shift significantly. The Everyday Liver Vitamin® provides support with clinically studied Bergacyn® FF and other bioavailable ingredients, crafted to help with fat metabolism and liver detox function during GLP-1 therapy.
It’s also important to understand how your body reacts to dosage changes or accidental overuse. If you’re ever unsure about symptoms after taking a higher dose than prescribed, this guide on what happens if you take too much Ozempic offers insights that can help you know when to seek guidance.
Final Thoughts
Ozempic can be a powerful tool for managing blood sugar and supporting weight goals, but it also introduces changes that affect how the body handles nutrition. Supplementing wisely can help maintain energy, digestion, and overall wellness, especially when appetite and food intake are reduced over time.
Zen Nutrients offers research-backed solutions crafted by pharmacists and physicians who understand the unique demands of GLP-1 therapy. Products like PeptideVite™ were designed specifically with Ozempic users in mind, combining clean, bioavailable ingredients that support digestion, energy, and nutrient replenishment in one daily formula.
Choosing the right support is ultimately personal. But when that support is built on clinical insight and crafted with care, it becomes easier to stay balanced while your health journey evolves. As always, talk with your healthcare provider before introducing new supplements, and adjust your routine based on how your body responds.
Read Also:
- Can This New Eye Vitamin Actually Help Athletes See Better?
- 5 Benefits of Bergacyn FF for Liver Health
- Does CoQ10 Help With Weight Loss?
Frequently Asked Questions About What Vitamins to Take with Ozempic
What should I avoid taking at the same time as Ozempic?
Avoid taking medications or supplements that irritate the stomach or compete for absorption, such as NSAIDs or high-dose iron, unless advised otherwise by your healthcare provider.
Do multivitamins interfere with Ozempic?
Multivitamins don’t interfere with the function of Ozempic. However, it’s best to take them with food and at a different time than your injection to reduce potential nausea.
Can Ozempic cause vitamin deficiencies over time?
While Ozempic doesn’t directly deplete nutrients, reduced food intake and slowed digestion may gradually impact nutrient levels, especially if not monitored.
Is it necessary to take supplements while on Ozempic?
Not always, but they can be helpful. Supplementation becomes more important if your diet is restricted, side effects impact nutrient absorption, or fatigue becomes an issue.
What kind of diet supports vitamin absorption while using Ozempic?
A diet rich in fiber, lean protein, and healthy fats supports both Ozempic’s effects and vitamin absorption. Small, nutrient-dense meals are ideal.
Can probiotics be taken with Ozempic?
Yes. Probiotics can support gut balance, especially if digestion feels sluggish. They do not interfere with the action of GLP-1 medications.
Are there natural alternatives to GLP-1 supplements like PeptideVite™?
Some herbs and whole foods offer similar support, but they typically lack the clinical dosing or combined formulation found in GLP-1-targeted supplements.
Should I get bloodwork done while using Ozempic?
Routine bloodwork can help monitor key vitamin and mineral levels, especially if you experience fatigue, weakness, or other symptoms over time.
Can I take magnesium with Ozempic?
Yes, magnesium may support muscle and nerve function. It’s best taken with food and not at the exact time as your Ozempic injection to avoid GI upset.
How long should I wait after taking Ozempic to take my vitamins?
Waiting a few hours after your injection to take vitamins may reduce the risk of stomach discomfort. Always follow the schedule that works best for your body.
Sources:
- Evans, A. (2025, April 29). 7 supplements to take with Ozempic, Wegovy, and other GLP-1-related medications. GoodRx. https://www.goodrx.com/classes/glp-1-agonists/supplements-to-take-with-ozempic
- Weiser, P. (2025, July 9). What vitamins to take with Ozempic (semaglutide) and why. Medical News Today. https://www.medicalnewstoday.com/articles/drugs-what-vitamins-to-take-with-ozempic
- Southern Weight Loss. The importance of taking multivitamins while using Ozempic. https://southernweightloss.co.nz/weight-loss-medication/the-importance-of-taking-multivitamins-while-using-ozempic/
- Joseph, Saju, Devan A. Patel, Jill Barat, and Teri A. Standridge. Clinical Nutrition & Supplements when using Glucagon-Like Peptide-1 (GLP-1) Agonists for Weight Loss. Clinical Research White Paper, June 2023. Shopify, https://cdn.shopify.com/s/files/1/0526/0892/5875/files/Clinical_Nutrition_Supplements_when_using_Glucagon-Like_Peptide-1_GLP-1_Agonists_for_Weight_Loss_2.pdf
DISCLAIMER:
The information in this article is for educational purposes only and has not been evaluated by the Food and Drug Administration. It is not intended to diagnose, treat, cure, or prevent any disease.
