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06th August 2024

Zepbound Dosage: How Much Zepbound To Use Week by Week

Dr. Jill Barat, PharmD
Zepbound Dosage: How Much Zepbound To Use Week by Week

Zepbound is an injectable medication meant to help people lose weight. Zepbound comes prepackaged in injection pens that are fully used up with each weekly dosage. So, there are not multiple uses in each pen, only one.

Your Zepbound dosage is normally increased over the course of many weeks to months. This slow increase is recommended to help people get the benefits of the medication without the side effects becoming too much. A slow ramp-up should help out with potential side effects like gastrointestinal issues.

So, since your dosage will likely be changing a few times until you find your long-term dosage, you might not be entirely sure about your dosage progression. In this article, we will cover the available pen strengths of Zepbound, the usual starting dosage, the common maintenance dosages, and what the progression to finding your dosage might look like.


What strengths do Zepbound pens come in?

Zepbound pens are available in the following single-use pen strengths:

2.5mg per 0.5ml (2.5mg per pen)

5mg per 0.5ml (5mg per pen)

7.5mg per 0.5ml (7.5mg per pen)

10mg per 0.5ml (10mg per pen)

12.5mg per 0.5ml (12.5mg per pen)

15mg per 0.5ml (15mg per pen)


What is the usual Zepbound starting dosage?

The usual Zepbound starting dosage is much lower than what will end up being your maintenance dosage. The usual starting dosage for Zepbound is 2.5mg once weekly for 4 weeks. After this time period, your dosage will likely be increased.

This lower starting dose is used to help ease your body into your treatment. This is meant to help reduce the amount or severity of side effects that you experience, especially the gastrointestinal side effects.


What is the usual Zepbound maintenance dosage?

What ends up being your Zepbound maintenance dosage will depend on how well the medication is working for you, and any side effects you are experiencing. Your maintenance dose can be thought of as your “long-term” dosage. This will be the dosage you stay at for the remainder of your Zepbound treatment plan.


In general, the 3 recommended maintenance dosages are:

5mg injected once weekly

10mg injected once weekly

15mg injected once weekly


The 15mg weekly dosage is also the maximum dosage for Zepbound.


What is the usual Zepbound dosage week by week

The suggested dosage increase week by week for Zepbound is shown below. Basically, you start on the started dosage, and then increase your dosage every 4 weeks by no more than 2.5mg each increase. Once you hit a maintenance dosage that works for you, you will remain there.

This example below is the week-by-week dosage for someone who progresses all the way to the highest 15mg dosage. But remember, that some people may also stop at the 5mg or 10mg dosage for their maintenance dose. You and your doctor may also decided that you stay on one of these steps for longer than 4 weeks before progressing, although the suggestion is 4 weeks per progressing dosage.

Week 1 through week 4: 2.5mg once weekly (starting dose)

Week 5 through week 8: 5mg once weekly (maintenance dose option)

Week 9 through week 12: 7.5mg once weekly

Week 13 through week 16: 10mg once weekly (maintenance dose option)

Week 17 through week 20: 12.5mg once weekly

Week 20 and onward: 15mg once weekly (maximum maintenance dose option)


PeptideVite for digestive comfort while using GLP-1 medications*

If you are on your Zepbound treatment journey, you might be on the lookout for ways to help avoid or reduce the possible side effects to make things go smoother. One possible option is including digestion-supporting supplements like PeptideVite to your daily regimen.*

PeptideVite was created by doctors and pharmacists to be paired with GLP-1 medications like Zepbound. The idea is that if you can feel more comfortable throughout your treatment, you might be able to stay on the treatment for longer to get the results you are hoping for.*

Learn more about PeptideVite from Zen Nutrients today.




*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.