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31st July 2023

Semaglutide Side Effects & How to Manage Them

Dr. Devan Patel, PharmD
semaglutide side effects

Semaglutide is an injectable medication belonging to the glucagon-like peptide-1 receptor agonists that are used to treat Type 2 diabetes.

More commonly known as Ozempic®, semaglutide therapy helps regulate blood sugar levels by stimulating insulin production and reducing glucose release from the liver. Semaglutide therapy has also been linked to weight loss and weight management. While semaglutide therapy is an effective treatment for diabetes, like any medication, it may come with some side effects.

5 Common Semaglutide Side Effects

Semaglutide is a great and effective therapy for those with diabetes—but it can have some not-so-great side effects. From fatigue to weight loss side effects, semaglutide therapy can have a major impact on your daily life. Common side effects from semaglutide treatment include:

1. Nausea and Vomiting

Some individuals may experience mild to moderate nausea and occasional vomiting when starting semaglutide therapy. Those with higher doses of semaglutide are more likely to experience nausea and vomiting. 

2. Acid Reflux

Yes, that burning sensation in your esophagus can be linked to semaglutide therapy. Semaglutide can lead to indigestion or heartburn in some patients. This is due to the way semaglutide therapy can affect your stomach.

3. Gastrointestinal (GI) Issues 

Gastrointestinal problems like diarrhea, constipation, abdominal pains, and excessive gas are relatively common side effects of semaglutide therapy. In fact, gastrointestinal problems are among the most common side effects when taking semaglutide therapy.

4. Dizziness

A few patients might experience dizziness or lightheadedness during the initial stages of semaglutide therapy. This can significantly disrupt daily activities, including household chores and driving. Dizziness can also be a sign of hypoglycemia—which occurs when your blood sugar level is too low.

5. Fatigue

Finally, some individuals may experience tiredness or fatigue as their body adjusts to semaglutide therapy.

How Long Do Semaglutide Side Effects Last?

It depends. Generally, these side effects tend to be more pronounced at the beginning of therapy and gradually subside within a few weeks. Several factors can influence how long side effects last, including the dosage of your semaglutide injections.

Talk to your doctor about the possibility of starting semaglutide therapy with a lower daily dose.

How to Manage GLP-1 Side Effects

You don’t have to suffer through Ozempic® side effects. Luckily, there are several ways to ease and manage them, allowing patients like you to continue treatment more comfortably.

Managing GI Side Effects

Eat Smaller Meals

Consuming smaller meals may help reduce the strain on your digestive system and alleviate symptoms like stomach pains and gas. Smaller meals may also help manage blood sugar levels.

Avoid High-Fat or Greasy Foods

Greasy, high-fat foods may taste good but can do a number on your gut. These foods can worsen GI issues. Instead, opt for a balanced diet with moderate fat content.

Eat High-Fiber Foods

Incorporating high-fiber foods into your diet can help manage constipation caused by semaglutide therapy. Add more foods like whole grains, beans, and fresh fruits and vegetables to your diet.

Get Exercise

Regular physical activity can promote better digestion and reduce GI discomfort. In other words, exercise can help move stools through your digestive tract.

Avoid Eating Right Before Bed

Careful, midnight snackers. Eating close to bedtime may exacerbate acid reflux and discomfort. Allow some time for digestion before lying down.

Try Digestive Supplements

Digestive supplements containing ingredients like bromelain—which is found in PeptideVite™—can aid in digestion and alleviate GI issues.

Managing Nausea

Stay Hydrated

Staying hydrated is essential during your semaglutide therapy. Drinking enough water can help prevent dehydration, which may worsen nausea.

Avoid Spicy Foods

Are you a spicy food lover? You might want to re-think your choices. These types of foods can trigger or intensify nausea and abdominal discomfort. Stay away from foods with strong odors as well. Particularly odorous foods can lead to nausea flare-ups.

Try Meditating 

Stress and anxiety can exacerbate nausea. Relaxation techniques may help steer symptoms away. Plus, meditation is a great way to carve out some quality you-time.

Try Ginger, Peppermint Tea, or Supplements Like PeptideVite©

Ginger and peppermint have natural anti-nausea properties and can be beneficial in easing nausea. Supplements like PeptideVite™ have also been known to provide relief for nausea and abdominal pain.

Managing Fatigue

Try Taking Walks

Gentle exercise can combat fatigue and boost energy.

Try Eating a Snack

If you engage in vigorous physical activity, having a small snack beforehand can provide additional energy.

Try Energy-Boosting Supplements

PeptideVite™ contains ingredients designed to support energy levels and reduce fatigue.

Why PeptideVite™?

PeptideVite™ is a supplement specially formulated to support individuals experiencing side effects from medications like Ozempic®. Its unique blend of ingredients—including bromelain, peppermint, and essential vitamins—can help manage GI discomfort, nausea, and fatigue. Here’s what PeptideVite™ can do for you:

  • • Support Energy Levels*
  • • Aid In Nausea & Abdominal Discomfort*
  • • Support Weight Loss & Weight Management*
  • • Promote Better Metabolism*
  • • Promote Adherence To GLP-1 Peptide Therapy*
  • • Support Muscle Mass Increase*


Our newest supplement is research-backed, physician-approved, and third-party tested. All of our products have gone through rigorous testing and are supported by pharmacists nationwide. While PeptideVite™ is safe to take with Ozempic®, you should always consult with your doctor before taking any supplements alongside your current medications.

Make Zen Nutrients’ PeptideVite™ Your Semaglutide Sidekick

When it comes to finding high-quality supplements to complement your healthcare journey, there's one name that stands out among the rest: Zen Nutrients. We’re a team of nutritionists, advisors, and scientists dedicated to your health and well-being. At Zen Nutrients, we offer a wide range of supplements that are carefully formulated to address your specific needs, like aiding semaglutide therapy.

By choosing Zen Nutrients, you can trust in the expertise and dedication of a company that prioritizes your health, ensuring that you have the support you need to achieve your wellness goals. Say goodbye to debilitating side effects and hello to PeptideVite™, your new semaglutide therapy sidekick.

Buy PeptideVite™

*Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.