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17th June 2024

Ozempic Constipation: Why Does It Happen and What To Do

Dr. Devan Patel, PharmD
Ozempic Constipation: Why Does It Happen and What To Do

Ozempic constipation. Yes, it’s a thing and if you are currently taking the popular weight loss medication, you’ve probably experienced it at some point during your treatment.  

Ozempic, or semaglutide, is a medication widely used to manage type 2 diabetes and, more recently, to aid in weight loss. While it offers significant benefits, it can also cause gastrointestinal discomfort, including constipation.

But why does Ozempic cause constipation and what can you do about it? Read below to find out more. 


How Ozempic Works

Ozempic belongs to a class of medications known as GLP-1 receptor agonists. These drugs mimic the action of the glucagon-like peptide-1 (GLP-1), a natural hormone that increases insulin secretion, slows gastric emptying, and reduces appetite. 

By slowing the digestive process, Ozempic helps maintain stable blood sugar levels and keep you feeling full, which aids in weight loss.

However, slowing down gastric emptying can also cause gastrointestinal side effects, including nausea, diarrhea, and notably, Ozempic constipation. The slowing of gastric emptying means that food stays in your stomach longer, potentially leading to decreased bowel movements and resulting in constipation.


What Causes Ozempic Constipation?

The primary reason Ozempic constipation occurs is because of the medicine’s effect on your stomach muscles. Contractions of the stomach muscles make it possible to move food through your digestive tract. 

By slowing these contractions, Ozempic helps control blood sugar levels and reduce appetite but it can also disrupt your normal digestive processes.

Additionally, Ozempic alters the absorption rate of nutrients and water in your intestines, which can make stool become harder and more difficult to pass. Not drinking enough water while on Ozempic, can worsen this issue, leading to Ozempic constipation.


How Can You Reduce Ozempic Constipation?

Ozempic constipation can be uncomfortable but there are lifestyle changes you can make to reduce your chance of becoming constipated. 

Increase Fiber Intake

Eating more fiber-rich foods such as fruits, vegetables, whole grains, and legumes can help add bulk to the stool and promote regular bowel movements. If eating more fiber doesn’t help, try over-the-counter fiber supplements like psyllium husk which may also be beneficial.

Stay Hydrated

Staying hydrated is crucial for preventing Ozempic constipation. Aim for at least eight glasses of water a day for best results. 

Additionally, reduce your intake of dehydrating beverages such as alcohol and caffeine, as these can contribute to dehydration and worsen constipation. 


Engaging in regular physical activity can stimulate intestinal activity and help reduce constipation. Even a daily walk can make a significant difference in reducing Ozempic constipation.

Over-the-Counter Remedies

Over-the-counter remedies like laxatives can help stimulate bowel movements, which can ease constipation. If laxatives don’t work, you can also try stool softeners. Stool softeners, well, soften your stool by adding more moisture to it, which can make it easier to pass. 


Probiotics are live bacteria that can promote a healthy gut microbiome and improve digestive health, potentially easing Ozempic constipation.

Adjust Your Dosage

Although Ozempic dosages start smaller and increase over time, everyone can be affected differently. If you’re experiencing side effects, talk to your doctor about your treatment. 

They may suggest adjusting your Ozempic dosage to an amount your body can better tolerate. 


Some dietary supplements may contain ingredients that can ease constipation. PeptideVite is a natural supplement with ingredients like ginger, digestive enzymes, and probiotics that have been studied for their effectiveness in reducing gastrointestinal symptoms.* 

The unique formula blend was formulated specifically for use alongside GLP-1 weight loss medications to ease side effects and help adherence to your Ozempic treatment plan.* 

When to Seek Medical Advice for Ozempic Constipation

While mild constipation can often be managed with lifestyle changes and over-the-counter remedies, it's important to seek medical advice if you experience severe or persistent constipation. Signs that warrant medical attention include:

Severe abdominal pain

Bloating or distension

Unexplained weight loss

Blood in the stool

Your doctor can assess your symptoms, rule out other potential causes, and provide the right course of action to ease your symptoms.


Ozempic Constipation: The Takeaway

Ozempic offers significant benefits for managing type 2 diabetes and aiding in weight loss, but it is not without side effects. Constipation, although common, can be effectively managed through dietary adjustments, hydration, physical activity, and, when necessary, medical intervention. 

By understanding the reasons behind Ozempic constipation and implementing these strategies, you can better manage your constipation and continue to reap the benefits of Ozempic.

Talk to your doctor before making any changes to your medication regimen or trying new treatments. With the right approach, you can navigate the challenges of Ozempic constipation and maintain your health and well-being.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.