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28th July 2023

Does Ozempic Need To Be Refrigerated? How To Store Ozempic

Dr. Devan Patel, PharmD
Does Ozempic Need To Be Refrigerated? How To Store Ozempic

Ozempic is an injectable medication for diabetics that helps them control their blood sugar. It’s administered in liquid form through a medical pen device similar to an EpiPen. 


Before administering an injection, Ozempic needs to be properly stored to maintain its freshness and effectiveness. But does Ozempic need to be refrigerated once it is opened?


Understanding the proper way to store your medication is especially important for those who are new to using the medication or switching from a different brand to Ozempic.


Below, we’ll discuss Ozempic in more depth and how to store it properly as well as answer the question, “Does Ozempic need to be refrigerated?”.


What Is Ozempic and How Does It Work?

Ozempic is a medication that is used to control high blood sugar levels in people with type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists


GLP-1 is a hormone in the body that helps to regulate blood sugar levels by increasing the production of insulin and decreasing the production of glucose. Ozempic mimics the effects of GLP-1, thereby regulating blood sugar levels in people with diabetes.


In addition to lowering blood sugar levels, Ozempic slows down digestion which decreases appetite and can result in weight loss. However, Ozempic is not intended to be a weight loss drug. 


Does Ozempic Cause Side Effects?

Like any medication, Ozempic can potentially cause side effects. The most common semaglutide side effects associated with Ozempic are gastrointestinal symptoms like nausea, bloating, diarrhea, and abdominal pain. In more extreme but rare cases, Ozempic may cause kidney problems and pancreatitis. 

You may be able to reduce the side effects of Ozempic by making lifestyle changes such as eating slower, eating smaller meals, avoiding greasy foods, and drinking more water. You may also benefit from taking a dietary supplement like PeptideVite.* 

PeptideVite is a multi-nutrient supplement formulated to help ease symptoms associated with taking medications like Ozempic.* The natural ingredients are researched for their potential to reduce symptoms like nausea, gas, and bloating.* Taking a dietary supplement like PeptideVite alongside your Ozempic medication may make your experience less uncomfortable.* 


Who Should Not Use Ozempic?

People who are allergic to semaglutide or any of the ingredients in Ozempic, should not use the medication. Additionally, do not use Ozempic if you or anyone in your family has a history of medullary thyroid cancer (MTC) or Multiple Endocrine Neoplasia syndrome type 2.

Talk to your doctor about all your medical conditions, especially if you currently have or have had kidney problems, gallbladder problems, pancreatitis, liver problems, a history of alcoholism, low blood sugar (hypoglycemia), or any other medical conditions.

Pregnant women or women planning to become pregnant, you should also not use Ozempic as it can harm an unborn baby. If you become pregnant while using Ozempic, stop taking it and contact your doctor immediately.


Does Ozempic Need to Be Refrigerated?

Yes, Ozempic needs to be refrigerated until the first time you use it to preserve its freshness and effectiveness. Keeping it at room temperature can decrease the effectiveness of the medication and increase the risk of spoilage. 

Can You Freeze Ozempic? 

Before use, Ozempic should be stored in the refrigerator at a temperature between 36°F and 46°F (2°C and 8°C). Do not freeze Ozempic, as this can cause it to become unusable.

Once the pen is open and in use, Ozempic can be stored at room temperature (between 59°F and 86°F) for up to 56 days. 

How Long Can Ozempic Be Stored in the Fridge?

Ozempic can be stored in the refrigerator or at room temperature for up to 56 days after it has been opened for the first time. Before using the medication, check the expiration date on the box to make sure it has not expired, or if it will expire during that 56 day window. 


If the medication has expired, do not use it and dispose of it properly, even if there is still some medication left in the pen. Unopened Ozempic can be used right up until the expiration date if it has been stored properly in the fridge.


Does Ozempic Need To Be Refrigerated When Traveling?

Yes, Ozempic should be kept refrigerated while traveling until you are ready to use it. You can use a portable cooler or insulated bag to keep the medication cool.  

Make sure to pack enough medication for the duration of your trip and bring extra in case of unexpected delays. If you are traveling by air, keep the medication in your carry-on bag to ensure that it remains at an appropriate temperature.

two portable coolers with ice

How Do You Dispose of Unused Ozempic?

Once Ozempic has expired, or if you have any unused medication, it is important to dispose of it properly. You can ask your pharmacist for advice on medication disposal or look up local regulations on prescription drug disposal. 


Do not dispose of medication in the trash or flush it down the toilet, as this can be harmful to the environment.


How To Store Ozempic: The Bottom Line

Proper storage and monitoring are essential for ensuring that Ozempic remains effective and safe for use. Always store Ozempic in the refrigerator until it is opened and keep it away from direct sunlight and heat. Once your Ozempic pen is in use, you can choose to continue storing it in the fridge, or you can then store it at room temperature for up to 56 days.


Make sure to check the expiration date before using the medication and dispose of any unused medication safely. By taking these precautions, you can ensure that your Ozempic remains a reliable part of your diabetes management plan.



*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.