29th March 2024

How To Use Wegovy Pen

Dr. Devan Patel, PharmD
How To Use Wegovy Pen

If you've been prescribed Wegovy (semaglutide) for weight loss, you may have questions about how to use the Wegovy pen properly. This once-weekly injectable medication has shown remarkable results in clinical trials, helping people lose up to 15% of their body weight. 

However, using the Wegovy pen correctly is crucial to ensure the medication's effectiveness and safety.

Keep reading for a step-by-step guide on how to use the Wegovy pen correctly and safely. 

What is the Wegovy Pen?

The Wegovy pen is a pre-filled, single-patient-use pen injector designed for self-administration. Each pen contains a fixed dose of semaglutide, which is slowly released into your body over the course of a week. 

The pen is color-coded based on the dosage strength, making it easy to identify the correct pen for your prescribed dose.

Before Using the Wegovy Pen

Before learning how to use the Wegovy pen, there are a few important preparations to keep in mind:


Store your unused Wegovy pens in the refrigerator between 36°F and 46°F (2°C and 8°C). Do not freeze or expose them to extreme heat.


Inspect the pen before use. If the solution is cloudy, discolored, or contains particles, do not use it.


Take the pen out of the refrigerator and allow it to reach room temperature before injecting. This usually takes around 20-30 minutes.

Step-by-Step Instructions on How to Use Wegovy Pen

Now that you've prepared your pen, it's time to learn how to use the Wegovy pen correctly. Follow these step-by-step instructions:

Wash Your Hands 

Start by washing your hands with soap and water to prevent infection.

Choose and Prepare the Injection Site

The recommended injection sites are the abdomen, thigh, or upper arm. Clean the injection site with an alcohol swab and let it air dry.

Remove the Pen Cap

Pull the pen cap straight off to expose the needle.

Prime the Pen

With the pen pointing up, gently tap the cartridge to bring any air bubbles to the top. Then, turn the dose selector until the dose counter shows the flow drop symbol (→). 

Press the dose button until a drop of solution appears at the needle tip. This step is important to ensure the pen is working correctly and to remove any air bubbles.

Select the Dose

Turn the dose selector to the prescribed dose. Do not push the dose button yet.

Inject the Dose: 

Insert the needle into your cleaned injection site at a 90-degree angle. Press the dose button until the dose counter returns to 0 and keep the needle in for at least 6 seconds before removing it.

Dispose of the Pen 

After each use, carefully dispose of the pen in a puncture-resistant container.

Tips for a Successful Injection

While learning how to use the Wegovy pen may seem daunting at first, it will become easier with practice. Here are some additional tips to ensure a smooth injection process:

  • Rotate injection sites: To avoid discomfort or skin issues, rotate injection sites with each dose.
  • Pinch the skin: For injections in the abdomen or thigh, gently pinch the skin before inserting the needle.
  • Maintain pressure: After the injection, apply gentle pressure to the injection site with a cotton ball or gauze to prevent bruising.
  • Stay hydrated: Drinking plenty of water before and after your injection can help minimize potential side effects like nausea.

Addressing Common Concerns

As with any new medication, it's natural to have concerns when learning how to use the Wegovy pen. Here are some common questions and their answers:

Q: What if I see air bubbles in the pen?

A: It's normal to see small air bubbles in the pen. Priming the pen before each use will remove any larger air bubbles.

Q: Can I reuse the pen for multiple doses?

A: No, each Wegovy pen is designed for single use only. Discard it after each injection.

Q: What if I accidentally inject the wrong dose?

A: If you inject too much or too little, contact your healthcare provider immediately for guidance.

Q: Are there any side effects of Wegovy? How can I manage them?

A: Like any medication, Wegovy can have side effects. The most common side effects are nausea and gastrointestinal symptoms. These symptoms are generally mild and subside after a few weeks. 

Staying hydrated, avoiding spicy or greasy foods, and considering supplements like PeptideVite may help to reduce side effect severity.* PeptideVite is an all-natural dietary supplement formulated specifically with ingredients that may reduce semaglutide side effects and make semaglutide use more manageable.*

Remember, if you have any specific concerns or questions about how to use the Wegovy pen, don't hesitate to reach out to your healthcare provider or pharmacist for personalized guidance.

How To Use Wegovy Pen: The Bottom Line

Learning how to use Wegovy pen correctly is an essential step in your weight loss journey with Wegovy. By following these step-by-step instructions, addressing common concerns, and incorporating helpful tips, you can ensure the safe and effective use of this weight-loss medication. 

Curious about Wegovy? Talk to your doctor to determine whether Wegovy may be right for you. 

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.