How Long Do Zepbound Side Effects Last?

Zepbound is the brand name medication that contains the active ingredient, Tirzepatide.

Zepbound is FDA-approved to help people who are overweight or obese lose weight. The goal is to help them achieve improved health and avoid or improve weight-related diseases like high blood pressure, high cholesterol, and diabetes.

This sounds great, but it’s important to be aware of the possible side effects, since most Tirzepatide users will experience some degree of mild to moderate side effects.

What are the possible common side effects of Zepbound?

If you do experience side effects with Zepbound, it is most likely that they will be some of these more common side effects. Luckily, these tend to go away with time, or can be managed with lifestyle or diet changes, or OTC medications.

The most common side effects of Zepbound are:

Nausea

Vomiting

Diarrhea

Constipation

Digestion upset

Abdominal pain

Fatigue

Reactions at the injection site

Note that this is not the full listing of possible side effects while using Zepbound. These are just the most common side effects of this medication. To see the full list of possible side effects take a look at the FDA prescribing information for Tirzepatide.

What are the possible less common but more severe side effects of Zepbound?

While these side effects are less likely to happen, they are more severe and should not be ignored.

The potential severe side effects of Zepbound include:

Intense digestive issues

Inflammation of the pancreas (pancreatitis)

Gallbladder issues including gallstones

Kidney problems

Too low blood sugar (hypoglycemia)

Severe allergic reaction

Suicidal behavior or thoughts

Risk of thyroid cancer [Black Box Warning]

If these issues, or signs of these side effects are happening while you are using Zepbound, it’s important to bring this up to your doctor. If symptoms are severe or a medical emergency, get emergency medical care immediately. If these severe side effects happen to you, it’s likely that this medication is not a good fit for you, and your doctor will likely discontinue your treatment.

How long do common Zepbound side effects last?

For the common, less severe Zepbound side effects, some people find that they only last for a few days to weeks. So, it may only be a temporary discomfort.

Also keep in mind that side effects may be worse when first starting on the medication and after dosage increases. After this, the effects may taper off.

However, if your side effects are severe, don’t seem to lessen with time, or are negatively affecting your day-to-day life – it’s worth bringing them up with your doctor. There may be some ways to help reduce these side effects to help you through your treatment.

What are some ways to help avoid or improve the possible side effects of Zepbound?

Certain diet and lifestyle changes may improve some of the more common gastrointestinal side effects.

Since many of these uncomfortable digestive issues come from indigestion and slowed intestinal transit, making healthier choices may lead to more comfort.

Try to avoid heavy, greasy, fatty, fried, or oily foods. These are more likely to cause issues. Also go for smaller meals to avoid discomfort after eating, or from food lingering in your stomach for too long.

Getting in some movement regularly, especially after eating can also help improve digestion symptoms. 

If these tips don’t help, talk with your doctor about OTC options for when you are feeling digestive upset. Some people find that certain herbal teas or supplements can help too.

PeptideVite from Zen Nutrients to aid in digestive comfort while using Tirzepatide*

Some users of Tirzepatide and similar medications may find improvements in their digestive symptoms by utilizing certain herbs, plant extracts, and minerals. The pharmacists and doctors at Zen Nutrients put together PeptideVite with a combination of these soothing ingredients just for people using injectable weight loss medications, to make the process a little smoother (and more comfortable).* Learn more about PeptideVite today, and see if it might help make your weight loss journey a more comfortable one.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.